AutomedicationFrancoV1, Main, Exploration, bibRecord, 000320

A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

Identifieur interne : 000320 ( Main/Exploration ); précédent : 000319; suivant : 000321

A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

Auteurs : Tracey M. D'Cunha [Canada] ; Alexandra Chisholm [Canada] ; Cecile Hryhorczuk [Canada] ; Stephanie Fulton [Canada] ; Uri Shalev [Canada]

Source :

Psychopharmacology [ 1432-2072 ] ; 2020.

RBID : pubmed:31811350

Descripteurs français

KwdFr :
- Aire tegmentale ventrale (effets des médicaments et des substances chimiques), Aire tegmentale ventrale (métabolisme), Animaux (MeSH), Autoadministration (MeSH), Comportement de recherche de substances (effets des médicaments et des substances chimiques), Comportement de recherche de substances (physiologie), Conditionnement opérant (effets des médicaments et des substances chimiques), Conditionnement opérant (physiologie), Dépendance à l'héroïne (psychologie), Dépendance à l'héroïne (sang), Ghréline (sang), Héroïne (administration et posologie), Leptine (sang), Motivation (effets des médicaments et des substances chimiques), Motivation (physiologie), Mâle (MeSH), Privation alimentaire (physiologie), Rat Long-Evans (MeSH), Rats (MeSH).
MESH :
- administration et posologie : Héroïne.
- effets des médicaments et des substances chimiques : Aire tegmentale ventrale, Comportement de recherche de substances, Conditionnement opérant, Motivation.
- métabolisme : Aire tegmentale ventrale.
- physiologie : Comportement de recherche de substances, Conditionnement opérant, Motivation, Privation alimentaire.
- psychologie : Dépendance à l'héroïne.
- sang : Dépendance à l'héroïne, Ghréline, Leptine.
- Animaux, Autoadministration, Mâle, Rat Long-Evans, Rats.

English descriptors

KwdEn :
- Animals (MeSH), Conditioning, Operant (drug effects), Conditioning, Operant (physiology), Drug-Seeking Behavior (drug effects), Drug-Seeking Behavior (physiology), Food Deprivation (physiology), Ghrelin (blood), Heroin (administration & dosage), Heroin Dependence (blood), Heroin Dependence (psychology), Leptin (blood), Male (MeSH), Motivation (drug effects), Motivation (physiology), Rats (MeSH), Rats, Long-Evans (MeSH), Self Administration (MeSH), Ventral Tegmental Area (drug effects), Ventral Tegmental Area (metabolism).
MESH :
- chemical , administration & dosage : Heroin.
- chemical , blood : Ghrelin, Leptin.
- blood : Heroin Dependence.
- drug effects : Conditioning, Operant, Drug-Seeking Behavior, Motivation, Ventral Tegmental Area.
- metabolism : Ventral Tegmental Area.
- physiology : Conditioning, Operant, Drug-Seeking Behavior, Food Deprivation, Motivation.
- psychology : Heroin Dependence.
- Animals, Male, Rats, Rats, Long-Evans, Self Administration.

Abstract

RATIONAL

Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors.

OBJECTIVES

We investigated the role of leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

METHODS

Rats self-administered heroin (0.1 mg/kg/infusion) for 10 days followed by 14 days of drug withdrawal. During withdrawal, rats were food restricted to 90% of their original body weight or were given free access to food. In experiment 1, we measured the plasma concentrations of leptin and ghrelin following heroin self-administration and withdrawal. In experiment 2, leptin was administered centrally (2.0 or 4.0 μg; i.c.v.) prior to a heroin-seeking test under extinction conditions. High density of both leptin and ghrelin receptors was previously identified in the ventral tegmental area (VTA), suggesting a direct effect on reward and motivation. Hence, we administered leptin (experiment 3; 0.125 or 0.250 μg/side), or ghrelin receptor antagonist JMV 2959 (experiment 4; 2.0 or 10.0 μg/side) directly into the VTA prior to the heroin-seeking test.

RESULTS

Chronic food restriction significantly decreased plasma levels of leptin and elevated plasma levels of ghrelin. Central administration of leptin had no statistically significant effect on heroin seeking. Intra-VTA administration of either leptin or JMV 2959 dose-dependently and selectively decreased heroin seeking in the food-restricted rats.

CONCLUSIONS

Leptin and ghrelin transmission in the VTA can modulate the augmentation of heroin seeking induced by chronic food restriction.

DOI: 10.1007/s00213-019-05415-9
PubMed: 31811350

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Conditioning, Operant (drug effects)</term>
<term>Conditioning, Operant (physiology)</term>
<term>Drug-Seeking Behavior (drug effects)</term>
<term>Drug-Seeking Behavior (physiology)</term>
<term>Food Deprivation (physiology)</term>
<term>Ghrelin (blood)</term>
<term>Heroin (administration & dosage)</term>
<term>Heroin Dependence (blood)</term>
<term>Heroin Dependence (psychology)</term>
<term>Leptin (blood)</term>
<term>Male (MeSH)</term>
<term>Motivation (drug effects)</term>
<term>Motivation (physiology)</term>
<term>Rats (MeSH)</term>
<term>Rats, Long-Evans (MeSH)</term>
<term>Self Administration (MeSH)</term>
<term>Ventral Tegmental Area (drug effects)</term>
<term>Ventral Tegmental Area (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Aire tegmentale ventrale (effets des médicaments et des substances chimiques)</term>
<term>Aire tegmentale ventrale (métabolisme)</term>
<term>Animaux (MeSH)</term>
<term>Autoadministration (MeSH)</term>
<term>Comportement de recherche de substances (effets des médicaments et des substances chimiques)</term>
<term>Comportement de recherche de substances (physiologie)</term>
<term>Conditionnement opérant (effets des médicaments et des substances chimiques)</term>
<term>Conditionnement opérant (physiologie)</term>
<term>Dépendance à l'héroïne (psychologie)</term>
<term>Dépendance à l'héroïne (sang)</term>
<term>Ghréline (sang)</term>
<term>Héroïne (administration et posologie)</term>
<term>Leptine (sang)</term>
<term>Motivation (effets des médicaments et des substances chimiques)</term>
<term>Motivation (physiologie)</term>
<term>Mâle (MeSH)</term>
<term>Privation alimentaire (physiologie)</term>
<term>Rat Long-Evans (MeSH)</term>
<term>Rats (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Heroin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Ghrelin</term>
<term>Leptin</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Héroïne</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Heroin Dependence</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Conditioning, Operant</term>
<term>Drug-Seeking Behavior</term>
<term>Motivation</term>
<term>Ventral Tegmental Area</term>
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<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Aire tegmentale ventrale</term>
<term>Comportement de recherche de substances</term>
<term>Conditionnement opérant</term>
<term>Motivation</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Ventral Tegmental Area</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aire tegmentale ventrale</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Comportement de recherche de substances</term>
<term>Conditionnement opérant</term>
<term>Motivation</term>
<term>Privation alimentaire</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Conditioning, Operant</term>
<term>Drug-Seeking Behavior</term>
<term>Food Deprivation</term>
<term>Motivation</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Dépendance à l'héroïne</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Heroin Dependence</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Dépendance à l'héroïne</term>
<term>Ghréline</term>
<term>Leptine</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Long-Evans</term>
<term>Self Administration</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Autoadministration</term>
<term>Mâle</term>
<term>Rat Long-Evans</term>
<term>Rats</term>
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<front><div type="abstract" xml:lang="en"><p><b>RATIONAL</b>
</p>
<p>Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>We investigated the role of leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Rats self-administered heroin (0.1 mg/kg/infusion) for 10 days followed by 14 days of drug withdrawal. During withdrawal, rats were food restricted to 90% of their original body weight or were given free access to food. In experiment 1, we measured the plasma concentrations of leptin and ghrelin following heroin self-administration and withdrawal. In experiment 2, leptin was administered centrally (2.0 or 4.0 μg; i.c.v.) prior to a heroin-seeking test under extinction conditions. High density of both leptin and ghrelin receptors was previously identified in the ventral tegmental area (VTA), suggesting a direct effect on reward and motivation. Hence, we administered leptin (experiment 3; 0.125 or 0.250 μg/side), or ghrelin receptor antagonist JMV 2959 (experiment 4; 2.0 or 10.0 μg/side) directly into the VTA prior to the heroin-seeking test.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Chronic food restriction significantly decreased plasma levels of leptin and elevated plasma levels of ghrelin. Central administration of leptin had no statistically significant effect on heroin seeking. Intra-VTA administration of either leptin or JMV 2959 dose-dependently and selectively decreased heroin seeking in the food-restricted rats.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Leptin and ghrelin transmission in the VTA can modulate the augmentation of heroin seeking induced by chronic food restriction.</p>
</div>
</front>
</TEI>
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<Day>11</Day>
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<Title>Psychopharmacology</Title>
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<ArticleTitle>A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.</ArticleTitle>
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<Abstract><AbstractText Label="RATIONAL" NlmCategory="BACKGROUND">Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">We investigated the role of leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Rats self-administered heroin (0.1 mg/kg/infusion) for 10 days followed by 14 days of drug withdrawal. During withdrawal, rats were food restricted to 90% of their original body weight or were given free access to food. In experiment 1, we measured the plasma concentrations of leptin and ghrelin following heroin self-administration and withdrawal. In experiment 2, leptin was administered centrally (2.0 or 4.0 μg; i.c.v.) prior to a heroin-seeking test under extinction conditions. High density of both leptin and ghrelin receptors was previously identified in the ventral tegmental area (VTA), suggesting a direct effect on reward and motivation. Hence, we administered leptin (experiment 3; 0.125 or 0.250 μg/side), or ghrelin receptor antagonist JMV 2959 (experiment 4; 2.0 or 10.0 μg/side) directly into the VTA prior to the heroin-seeking test.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Chronic food restriction significantly decreased plasma levels of leptin and elevated plasma levels of ghrelin. Central administration of leptin had no statistically significant effect on heroin seeking. Intra-VTA administration of either leptin or JMV 2959 dose-dependently and selectively decreased heroin seeking in the food-restricted rats.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Leptin and ghrelin transmission in the VTA can modulate the augmentation of heroin seeking induced by chronic food restriction.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>D'Cunha</LastName>
<ForeName>Tracey M</ForeName>
<Initials>TM</Initials>
<AffiliationInfo><Affiliation>Department of Psychology, Concordia University, Montreal, Quebec, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Studies in Behavioral Neurobiology (CSBN), Montreal, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chisholm</LastName>
<ForeName>Alexandra</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Psychology, Concordia University, Montreal, Quebec, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Studies in Behavioral Neurobiology (CSBN), Montreal, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hryhorczuk</LastName>
<ForeName>Cecile</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Center for Studies in Behavioral Neurobiology (CSBN), Montreal, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre de Recherche du CHUM, Montreal Diabetes Research Centre, Université de Montréal, Quebec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
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A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

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